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comparison studies of actonel and fosamax
alendronate (a LEN droe nate)

What is the most important information I should know about Fosamax?
• Some forms of alendronate are taken once a day comparison studies of actonel and fosamax. Others are taken onlyonce a week comparison studies of actonel and fosamax. It is very important that you follow your doctor's directions comparison studies of actonel and fosamax. If you take alendronate once a week, take it on the same day each week comparison studies of actonel and fosamax.
• After swallowing the tablet, do not lie down, remain fully upright sitting,standing or walking, for at least 30 minutes and until after you have eaten comparison studies of actonel and fosamax.
• Do not crush, chew, or suck the tablets comparison studies of actonel and fosamax. Swallow them whole comparison studies of actonel and fosamax.
• Do not take alendronate at bedtime or before getting up for the day comparison studies of actonel and fosamax.

What is alendronate?
• Alendronate is a compound that alters the cycle of bone formation andbreakdown in your body comparison studies of actonel and fosamax. alendronate increases new bone formation comparison studies of actonel and fosamax.
• Fosamax is used to treat and prevent osteoporosis and to treat Paget'sdisease comparison studies of actonel and fosamax. Fosamax is also used to treat osteoporosis that is caused by treatmentwith a corticosteroid comparison studies of actonel and fosamax.
• Fosamax may also be used for purposes other than those listed in thismedication guide comparison studies of actonel and fosamax.

Who should not take Fosamax?
• Before taking Fosamax, tell your doctor if you
· have a problem swallowing, such as a narrowing of your esophagus;
· have esophageal ulcers or an esophageal disease;
· have a condition that causes low levels of calcium in your body;
· have kidney disease;
· have stomach ulcers or other stomach or digestive problems; or
· are unable to stand or sit upright for at least 30 minutes comparison studies of actonel and fosamax.
• You may not be able to take Fosamax, or you may require a lower doseor special monitoring during treatment if you have any of the conditions listedabove comparison studies of actonel and fosamax.
• Fosamax is in the FDA pregnancy category C comparison studies of actonel and fosamax. This means that it is notknown whether Fosamax will harm an unborn baby comparison studies of actonel and fosamax. Do not take Fosamax withoutfirst talking to your doctor if you are pregnant comparison studies of actonel and fosamax.
• It is also not known whether Fosamax passes into breast milk comparison studies of actonel and fosamax. Do nottake Fosamax without first talking to your doctor if you are breast-feedinga baby comparison studies of actonel and fosamax.

How should I take Fosamax?
• Take Fosamax exactly as directed by your doctor comparison studies of actonel and fosamax. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain them to you comparison studies of actonel and fosamax.
• Some forms of alendronate are taken once a day comparison studies of actonel and fosamax. Others are taken onlyonce a week comparison studies of actonel and fosamax. It is very important that you follow your doctor's directions comparison studies of actonel and fosamax. If you take alendronate once a week, take it on the same day each week comparison studies of actonel and fosamax.
• Take Fosamax first thing in the morning, at least 30 minutes before youeat any food or drink any liquid (other than plain water) comparison studies of actonel and fosamax. This timing is veryimportant for getting the maximum amount of medication from each dose comparison studies of actonel and fosamax. Foodsand beverages greatly decrease the effect of Fosamax comparison studies of actonel and fosamax.
• Take each dose with a full glass (6 to 8 ounces) of tap water or bottledwater comparison studies of actonel and fosamax. Taking each dose with a full glass of water will ensure proper swallowingof the tablet and reduce the risk of mouth or throat irritation comparison studies of actonel and fosamax. Do not takethis medication with mineral water, juice, or any other beverage comparison studies of actonel and fosamax.
• After swallowing the tablet, do not lie down, remain fully upright sitting,standing or walking, for at least 30 minutes and until after you have eaten comparison studies of actonel and fosamax.
• Do not crush, chew, or suck the tablets comparison studies of actonel and fosamax. Swallow them whole comparison studies of actonel and fosamax.
• Do not take Fosamax at bedtime or before getting up for the day comparison studies of actonel and fosamax.
• If you have difficulty or pain upon swallowing, chest pain, or new orworsening heartburn, stop taking Fosamax and call your doctor comparison studies of actonel and fosamax.
• It is important that you continue taking Fosamax for as long as yourdoctor prescribes it comparison studies of actonel and fosamax. Fosamax can treat or prevent osteoporosis only if youcontinue to take it comparison studies of actonel and fosamax.
• Store Fosamax at room temperature away from moisture and heat comparison studies of actonel and fosamax.

What happens if I miss a dose?
• If you take alendronate every day and you miss a dose, skip that doseand take your next regularly scheduled dose the following day comparison studies of actonel and fosamax. Missing one dosewill not affect your treatment comparison studies of actonel and fosamax. Do not take two tablets at the same time comparison studies of actonel and fosamax.
• If you take alendronate once a week and you miss a dose, take the misseddose on the morning after you remember comparison studies of actonel and fosamax. Do not take two tablets on the sameday comparison studies of actonel and fosamax. Return to taking one tablet once a week, as originally scheduled on yourchosen day comparison studies of actonel and fosamax.

What happens if I overdose?
• Seek emergency medical attention comparison studies of actonel and fosamax.
• The symptoms of an Fosamax overdose are unknown, but the following symptomsmight be expected: nausea, heartburn, pain in your abdomen, other stomach-relatedsymptoms, muscle cramps, uncontrollable facial grimacing, seizures, irritability,and abnormal behavior comparison studies of actonel and fosamax.

What should I avoid while taking Fosamax?
• Follow you doctor's recommendations about drinking alcohol and smoking comparison studies of actonel and fosamax. These activities are related to decreased bone density comparison studies of actonel and fosamax.

What are the possible side effects of Fosamax?
• Stop taking Fosamax and seek emergency medical attention or contact yourdoctor immediately if you experience any of the following serious side effects:
· an allergic reaction (difficulty breathing; closing of your throat;swelling of your lips, tongue, or face; or hives);
· difficulty or pain when swallowing;
· chest pain;
· pain or burning under your ribs or in your back; or
· new or worsening heartburn comparison studies of actonel and fosamax.
• Other, less serious side effects may be more likely to occur comparison studies of actonel and fosamax. Continueto take Fosamax and talk to your doctor if you experience
· abdominal discomfort;
· stomach upset, nausea, vomiting, diarrhea, or constipation;
· headache;
· muscle, bone, or joint soreness or aches;
· eye pain;
· a rash; or
· an altered sense of taste comparison studies of actonel and fosamax.
• Side effects other than those listed here may also occur comparison studies of actonel and fosamax. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome comparison studies of actonel and fosamax.

What other drugs will affect Fosamax?
• Antacids and other medicines taken by mouth may decrease the effectsof Fosamax comparison studies of actonel and fosamax. Do not take any other medicines within 30 minutes after a dose ofFosamax comparison studies of actonel and fosamax. Talk to your doctor before taking any other medicines during treatmentwith Fosamax comparison studies of actonel and fosamax.
• Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen(Motrin, Advil, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), indomethacin(Indocin, Indocin SR), naproxen (Anaprox, Aleve, Naprosyn), oxaprozin (Daypro),nabumetone (Relafen), piroxicam (Feldene), and others may increase the riskof damage to your stomach if they are taken during treatment with Fosamax comparison studies of actonel and fosamax. Talkto your doctor before taking anti-inflammatory medications, pain relievers orfever reducers during treatment with Fosamax comparison studies of actonel and fosamax.
• Drugs other than those listed here may also interact with Fosamax comparison studies of actonel and fosamax. Talkto your doctor and pharmacist before taking any prescription or over-the-countermedicines comparison studies of actonel and fosamax.

Where can I get more information?
• Your pharmacist has more information about Fosamax written for healthprofessionals that you may read comparison studies of actonel and fosamax.

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